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Ethics declarations Ethics approval and consent to participate Samples were collected in line with the Dutch Code for Proper Secondary use of Human Tissue ( and the local Medical Ethical Committee (protocol number 16-4-181)

The finding that NF-B controls the expression of vascular endothelial growth factor (VEGF) thus contributing to tumor angiogenesis can give support to the possible involvement of NF-B signaling in the mechanism of the effects of RBP4

Salazar-Roa and Malumbres, 2017

These factors include age, sex, existing comorbidities, targeted symptoms, blood biomarkers, and specific treatment protocols, before fully endorsing the use of omega-3 PUFAs either as an independent treatment or in conjunction with other medications for migraine management (80)

BPC-157 (Body Protection Compound-157) is widely researched for its role in supporting cellular repair pathways, vascular integrity, and soft tissue research models