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In cellular and animal models of steroid insensitivity mediated by oxidative stress, S-CMC restored steroid sensitivity by increasing HDAC-2 expression/activity through elevating GSH and SOD levels, reducing oxidative stress, enhancing HDAC-2 recruitment and reducing H4 acetylation in the IL-8 promoter region, and eventually alleviating inflammation and lung damage [88, 89]

P., Davis D

Caffeine was used as an internal standard

Studies have confirmed that liver organoids express key enzymes, including members of the cytochrome P450 (CYP450) family and hepatic transporters, though often at lower levels compared to native liver tissue 14,15

761 Moreover, NAFLD and NASH are frequently linked to metabolic disorders like obesity and diabetes, which further complicate the livers ability to repair and regenerate