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ACSL4 acylates AA, and subsequently, LPCAT3 catalyzes the acylated AA to membrane PL, which raises the oxidation of membrane-sensitive fatty acids such as PUFA, ultimately leading to lipid peroxidation [73]

A cross-sectional study found a significant correlation between the severity of DPN and the progression of diabetic retinopathy, suggesting overlapping pathogenic pathways and the need for integrated management approaches

TLR2 polymorphism TLRs are PRRs that mediate the recognition of foreign antigens by the innate immune system (110)

A reduction in Mg disrupts ATP stability and phosphate transfer reactions, which act as early metabolic signals of deficiency

However, results can vary , and more research is needed to determine their full effectiveness