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Lessons learned from particle toxicology for future Nanotoxicology The early observations in the mining industry in early 1900s up to late 1970s between exposure to particles and fibres and the diseases they have produced have prompted investigators to conduct in vivo animal and in vitro cell culture studies [312,313,314]

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While the RS CTD maintained this slight preference, its overall interactions with the linker DNA were substantially reduced due to de novo contacts of this CTD with itself (Fig

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