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doi: 10.1016/j.chemosphere.2022.135196 81 NoulasC.TziouvalekasM.KaryotisT

Altogether, these findings underscore the gut as a metabolically and immunologically active organ whose redox homeostasis is central to the aging process, and which is highly sensitive to disruptions in sleep architecture

Pharmacodynamic endpoints included total/LDL cholesterol, liver enzymes, and thyroid hormones

Decreased levels of hydroxyl radical (HO), peroxynitrite (ONOO - ), RO 2 , and singlet oxygen, and decreased expression of COX-2 and iNOS and NF-kB activation are all antioxidant effects of melatonin (318, 319), pointing to the possibility that melatonin is beneficial in UC by lowering inflammation and regulating OS

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