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Epigenetics as a mediator of plasticity in cancer

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Introduction Autologous chondrocyte implantation (ACI) is a biomedical treatment that repairs cartilage injury in the knee joint, which has been shown to reduce pain and facilitate mobility recovery ( Typically, ACI involves harvesting cartilage, isolating chondrocytes, expanding cells in vitro , and re-implanting over an articular cartilage defect