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Zhao Y, Li D, Wang S, Zhao W, Zhang Z, Zhang H et al (2024) Clinical formulation Zhigan oral liquid intervenes in alcoholic liver injury by regulating the intestinal flora and PI3KAKTNF-B pathway

Although both ROS and RNS are essential for many cellular functions, they require strict regulation by antioxidant systems

Additionally, multiple studies have indicated that the inhibition of the Nrf2/HO-1 pathway is associated with ferroptosis in conditions such as diabetic nephropathy 66 , transplanted islets 67 , acute lung injury 68 , and blood-brain barrier dysfunction 69

Balmant BD, Fonseca DC, Prudncio APA, et al

This increase is linked to visible changes in elastic fibers and an increase in skin wrinkles