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This ischemic environment can activate a series of intracellular cascade reactions, including excitotoxicity, inflammatory responses, glial cell activation, and neuronal apoptosis (67)

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The transcriptional activation of hepatic FGF21 increases whole-body energy expenditure, which contributes to reduced adiposity by SAAR (9)

Involvement of P2X7 receptors in the regulation of neurotransmitter release in the rat hippocampus