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To obtain the cytoplasm and cytosol, the hearts were washed in ice-cold homogenisation buffer (250 mM sucrose, 10 mM HEPES, and 1 mM EGTA, pH 7.4), homogenised in 2 ml buffer and centrifuged at 700 g for 10 min at 4 C to remove unbroken tissue and nuclei

Unaltered levels of glutathione status in lung tissue of ApoE -/- mice after pulmonary exposure to CB and/or LPS As a measure of oxidative stress, total and reduced glutathione were measured in lung homogenate 24 h after last exposure (Fig 3)

Inducers of CYP3A4 The concomitant use of ENDOCET and CYP3A4 inducers, such as rifampin, carbamazepine, and phenytoin, can decrease the plasma concentration of oxycodone [see CLINICAL PHARMACOLOGY], resulting in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence to ENDOCET [see WARNINGS]

They suggested aspartame could affect glucose tolerance and insulin levels and called for further research into the benefits and drawbacks of this sweetener for people with diabetes