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Any changes in the rats body composition were measured by time-domain nuclear magnetic resonance (TD NMR), as well as through the collection of organ and muscle tissue [3]

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

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10.1016/j.smim.2015.03.007 36 ConsoleL.ScaliseM.IndiveriC