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As for pharmacological studies, DNIs are sourced from pharmacokinetic data from studies with mostly small numbers of subjects, focusing only on the clinical relevance of the interaction, with some focusing on the mechanism behind the interaction

Frana MER, Ramos RKLG, Oliveira WH, Duarte-Silva E, Arajo SMR, Los DB, et al

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Conversely, our observation of elevated GSSG in cells lacking MPC1 (Figure 8B) suggests that, at a minimum, GSSG is not incompatible with diminished sensitivity to NAFLD