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Many of these trials do not adhere to the standards required for high-quality clinical research, such as adequate blinding and randomization, further diminishing their credibility

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The two rostral burr holes were placed just basal from the posterior interocular line, the two basal burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the two middle burr holes were placed in line between the basal and rostral burr holes

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