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doi: 10.1172/JCI14002 85

Comparing responses of dairy cows to short-term and long-term heat stress in climate-controlled chambers

Therefore, the signaling pathway mediated by 3-HKA activation of metabolic glutamate receptor 4(mGluR4) that promotes the conversion of astrocytes to the neuroprotective A2 phenotype and ultimately induces angiogenesis, and the neuroprotective effects provided by KYNA through antagonizing NMDAR and exerting antioxidant effects, synergistically constitute a dual neurovascular protective mechanism