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MadsenKLBuchAECohenBHFalkMJGoldsberryAGoldsteinAet al

Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

Compared with the CN group, the number of dark neurons in the Purkinje cell layer was notably reduced in the CP group (0.665 0.335/10 m 2 with P = 0.0117) and glycitin treatment groups [F (5, 30) = 14.16, P = 0.0029] at doses of 5, 10, and 20 mg/kg (0.495 0.165/10 m 2 with P = 0.0075, 0.18 0.18/10 m 2 with P = 0.0035, and 0.165 0.165/10 m 2 with P = 0.0033 respectively, Figures 4EI)

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