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In summary, development defects in the CNS in GDH-HI patients could be caused by multiple factors, including chronic hyperammonemia, and hyperinsulinemia, the more detailed mechanisms need to be further studied

doi: 10.1038/s41585-020-0346-4 48 WangSWangJChenZLuoJGuoWSunLet al

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Low serum B12 can mean that tissues are competing for limited holoTC in the bloodstream, and areas with high B12 turnover (including the bone marrow) may get priority, while the brain, liver and peripheral nerves do not receive enough