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Furthermore, MT-2 may increase thyrotropin-releasing hormone expression, which is associated with satiety and food intake

10.1021/jm100054f 41 FanM.YangK.WangX.WangY.TuF.HaT.et al (2020)

that is, if 14 patients were treated for 4 years with metformin 850 mg t.d.s., one would develop vitamin B12 deficiency

Direction of Future Research A multicenter randomized clinical trial is current in progress in Spain primary health-care setting called Project OB12 ( Conclusion Oral vitamin B12 replacement at 1000 g daily is an adequate alternative to IM B12 injections

If a patient is severely deficient, a physician might recommend an injection every other day or daily for the first week to rapidly saturate the bodys tissues