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Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor

TawkRGGrewalSSHeckmanMGRawalBMillerDAEdmonstonDet al

Additional findings include the presence of epithelial cell-derived proteins associated with ferroptosis in plasma exosomes from pSS patients, the potential involvement of complement C5 and C9 in ferroptosis, and variations in the levels of ferroptosis-related proteins in the exosomes being more reflective of epithelial cell pathology compared to plasma

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Singh et al, 2021), Genes common among published target sets include those related to redox biology (i.e., GCLC , SLC7A11 , TXN ) and the pentose-phosphate pathway (PPP, i.e., PGD , TALDO1 ), in addition to many NADP-dependent metabolic enzymes (i.e., AKR1C1 , AKR1B10 , and CYP4F11 )