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Soluble Vascular Adhesion Protein-1 Mediates Spermine Oxidation as Semicarbazide-Sensitive Amine Oxidase: Possible Role in Proliferative Diabetic Retinopathy

NAD is found in more chemical reactions within every single cell of the body than any other vitamin-derived molecule

Research Article - (2018) Volume 7, Issue 4 Oun Al-iedani 1,2 , Karen Ribbons 2 , Rod Lea 2 , Saadallah Ramadan 1,2* and Jeannette Lechner-Scott 2,3,4 1 School of Health Sciences, University of Newcastle, Callaghan, NSW 2308 Australia 2 Hunter Medical Research Institute, Newcastle, Australia 3 Department of Neurology, John Hunter Hospital, Newcastle, NSW Australia 4 School of Medicine and Public Health, University of Newcastle, Callaghan, NSW Australia Corresponding Author: Saadallah Ramadan School of Health Sciences, Faculty of Health and Medicine University of Newcastle, Callaghan, NSW 2308 Australia Tel: +61240420573 E-mail: [email protected] Received Date: Nov 20, 2018

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While BCKDH and HACL1 are (as indicated above) TPP-dependent enzymes, their activity is rarely reported in the context of thiamine deficiency, with the majority of studies focusing on TKT and PDH or KGDH as indicators of oxidative stress (TKT) and mitochondrial dysfunction (PDH or KGDH)