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Notably, 4-HNE can activate the mitochondrial ROS-mediated AKT/NF-B signaling pathway and increase MMP2 production in VSMCs (123)

Mechanism of action of sulforaphane: inhibition of p38 Mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response elementmediated heme oxygenase-1 in human hepatoma HepG2 cells