gst glutathione transferase Glutathione-S-Transferases as Potential Targets for Modulation of Nitric Oxide-Mediated Vasodilation GST family and cellular localization

[DOI] [PubMed] [Google Scholar] 51.Kum-Tatt L, Tan IK

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Mechanistically, NETosis provides a biologically plausible link: NETs and NET-derived components (histones, MPO, NE, extracellular DNA) induce endothelial activation and dysfunction and promote platelet capture, fibrin deposition, and contact-pathway/coagulation activation, thereby converting neutrophil priming into endothelial injury and microvascular thrombotic events [69]

This narrow focus may limit the models applicability in more comprehensive cases of fibrosis