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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

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Folic acid also contributes to normal blood formation and helps reduce tiredness and fatigue

Thats because excess body weight increases abdominal pressure, making it more likely for stomach acid to backflow

Zhang JZ, Ding Y, Xiang F, Yu SR, Zhang DZ, Guan MM, Kang XJ (2020) Effectiveness and safety of different doses of pioglitazone in psoriasis: a meta-analysis of randomized controlled trials