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Although current evidence supports a sophisticated mechanistic framework linking lactate-mediated hepcidin induction to ferroptosis, the tissue- and cell-type-specific effects of elevated lactate levels induced by diverse physiological and pathophysiological processes on iron homeostasis and ferroptosis throughout the body warrant further investigation

Structural prediction by Alphafold 2 (AF2) 43 and AF3 44 revealed a short stretch with weak helical potential (P345-Q361), called Axin LIR (Fig

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Berberine protects secondary injury in mice with traumatic brain injury through anti-oxidative and anti-inflammatory modulation