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Glutathione peroxidase (GPx) enzymes, which include GPx-1 and GPx-2, are crucial for cellular protection against oxidative damage, as these enzymes catalyze the reduction of lipid hydroperoxides to alcohols and convert free hydrogen peroxide into water, thereby preventing lipid peroxidation of cell membranes

this can be explained by the effect of VCN on the enhanced activity of the antioxidant nuclear transcriptional factor Nrf2 (a transcription factor that regulates cell responses to oxidative stress and protects against oxidant injury) as was observed in the gene expression analysis of the lung tissue, and supported by a previous study demonstrating the effect of VCN on oxidative stress-induced hepatotoxicity in vitro and in vivo by stabilizing the Nrf2 and preventing its proteasomal degradation via inhibiting the binding of Keap1 and Nrf2 83

het is goed denkbaar dat alfaliponzuur (naast niacinamide) invloed heeft op het ziekteproces.(43) Meer dan vijftig jaar geleden, nog voor de komst van antipsychotica, is in twee kleine studies waargenomen dat een lage dosis alfaliponzuur psychiatrische symptomen vermindert bij een deel van de proefpersonen met schizofrenie.(43) 4

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