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Conclusion: A novel validated model based on AST, AST/ALT ratio, serum bilirubin is more accurate compared to the current clinical criteria, for clinical diagnosis of AH and for recruitment of patients into clinical trials

Third, although our study highlighted the effect and underlying mechanism of AIF3 splicing-triggered mitochondrial disfunction, it remains unknown whether mitochondrial dysfunction alone is essential and sufficient to cause neurodegeneration and neuronal cell death

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Complement Protein Inhibitors The complement system plays essential roles in innate and adaptive immunity, contributing to inflammation and formation of the membrane attack complex (MAC) on cells