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Hence, piperine may prove to be a useful therapeutic agent not only for restricting attachment of virus to the host cells but also for targeting the cytokine storm by suppressing the activity of NF-B and MAPK pathways and subsequent pro-inflammatory cytokines release (Maurya et al., 2020)

Postmortem studies have revealed the aggregation of -synuclein in neurons around pigment-associated lipids under oxidative conditions, and this aggregation may participate in neuronal death in PD (Halliday et al., 2005)

Ischemia reperfusion (I/R) injury model: reducing ischemic injury and restoring barrier function Intestinal ischemia-reperfusion injury is common in clinical scenarios such as shock and surgery, which can lead to epithelial cell necrosis and barrier damage

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