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Another study investigating the effects of 4-HNE on cardiomyocyte DNA repair capacity reported that the activity of 8-oxoguanine DNA glycosylase 1 (OGG1), a key enzyme responsible for repairing oxidative DNA damage, was significantly reduced in the myocardium of db/db mice, accompanied by elevated 4-HNE adduct levels

The transcriptional control of genes unique to this stage of germ cell development has been linked to the important roles of lncRNA-Tcam1 and lncRNA-HSVIII in pachytene spermatocytes

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Together they represent a multi-target approach to tissue biology research