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16 Dysregulated mitochondrial ROS production is a feature of smokers with COPD 17,18 that is not limited to the lungs

Rights and permissions About this article Cite this article Moghaddam, B., Javitt, D

& Kruk, J

The mTOR signaling pathway promotes the anabolism of biological macromolecules, such as lipids, proteins and nucleotides, by integrating intracellular and extracellular signals, and inhibits autophagy to sustain cell survival (51)

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