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10.1111/jnc.15807 J

M., Giles, G

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GDNF preferentially binds to GDNF family receptor (GFR) to form a complex, which then associates with the Ret receptor, triggering downstream signaling cascades such as PI3K/Akt, MAPK/ERK, and Src kinase pathways, thereby exerting trophic effects on dopaminergic neurons [13] (Fig