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The SCFA-receptor interaction represents a direct molecular link in the gut-kidney axis, translating microbial metabolite production into renal protective signaling (Xiang et al., 2025)

However, inclusion of this study in meta-analyses of eight cohort studies showed that the risk of type 2 diabetes mellitus was inversely correlated with magnesium intake (73)

The -glutamyl moieties (BEAGA), which could be hydrolyzed to primary amines by the GGT enzyme, were incorporated into another terminal of the polymer

However, an overproduction of probiotic metabolites like peptidoglycan fragments or bacterial DNA can hyperactivate DCs via TLR2/9 or NOD2, boosting BAFF/APRIL production via NF-B/MAPK pathways, potentially triggering systemic autoreactive B cells and exacerbating SLE autoimmunity (139141)

Pharmaceuticals , 18(2), 185