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Interventions targeted at reducing inflammation have become increasingly popular among both IBD patients and healthy individuals since inflammation impacts brain tissue and their cognitive abilities ( The gut microbiota has evolved more pathogenically over time due to succession and within-host evolution, which may have caused unique microbial traits in MDD patients of different ages (98)

In the LPS-induced inflammatory model, butyrate supplementation improved gut morphology and reduced inflammation, evidenced by increased villus height and villus height-to-crypt depth ratio, while lowering inflammatory markers such as NF-B and IL-1, thereby contributing to intestinal integrity

This conflicts with immune checkpoint inhibitor studies reporting closer proximity between tumor and T-cells compared to macrophage and T-cells post-therapy, corresponding to improved therapeutic response (32)

Overall, colonization and pathogenesis of C