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Within the setting of hypertension, the activation of the reninangiotensin system by Ang II can substantially increase TNF- expression at both the mRNA and protein levels [239]

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This hypothesis is supported by increases in pro-inflammatory cytokines (IFN-, TNF-, IL-6) observed 26 days post-infection in the lungs of gsh2 -infected mice, which are absent in these mice 14 days post-infection (Extended Data Fig

An important note for the research community: afamelanotide is the INN (International Non-proprietary Name) assigned to Melanotan 1 following clinical development