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10.2741/2070 Front

Several non-pharmacological approaches have also been studied, including physical rehabilitation, hypoxia/ischemia, and hypothermia

Classic example with conjugation occurring after introduction of a nucleophilic site (phenol) Kamata et al Drug Metabolism Disposition 2006 Many compounds or drugs contain functional groups that can be directly conjugated and thus do notrequire Phase I metabolism to create handles (nucleophiles) for conjugation.Ciprofloxacin Propranolol BilirubinDiflunisal Acetaminophen Thyroxine (T4)Q

In other instances, these ingested substances can stimulate melanin production, thus precipitating a color change

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