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Results: B7h4 was highly expressed in ~60% of iCCAs, mainly cold tumors

Single-agent inhibition is unlikely to provide durable benefit in controlling advanced disease 17 and recent studies report CB-839 synergizes with -lapachone in PDAC 55 and BCL-2 inhibition in acute myeloid leukaemia 31

PMID: 30575801

Besides very high radiation doses above 50 Gy, which are irrelevant to human experience, there are no symptoms or clinical signs in the first 6 months after irradiation