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Life Sci 31:11511159 Carter CJ (1983) Glutamine synthetase and fructose-1, 6-diphosphatase activity in the putamen of control and Huntingtons disease brain post mortem

Inspired by NCL, in this work, we extended this approach and explored the use of 2-aminothiols for the deprotection of thiols bearing an acyl group

We speculate that the emergence of the N-terminal hydrophobic region in vertebrates reflects a domain-gain event during evolution, which enabled neofunctionalization towards roles in mediating endoplasmic reticulum (ER) stress responses 54 and facilitating physical contacts between the ER and mitochondria 55

The funders had no role in the design of the study, in the collection, analysis, and interpretation of data, or in writing the manuscript

JHU083 JHU083 is a prodrug form of L-DON designed to be cleaved by tissue proteases and other enzymes in the cancer, thereby limiting its effects on other organs [87, 102] (Fig