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The high level of O 2 partial pressure in tissues stimulates neovascularization and enhances phagocytosis and leukocyte-mediated killing of pathogens at the wound site

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Thus, dynamic variation in alveolar p O 2 and its effect on cellular redox state may impose a direct role in modulating the pattern of gene expression and, thus, could be crucial in determining cellular fate and the inflammatory process regulated by cytokines [3646, 166, 164]