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The question is not whether the mechanism makes sense but whether clinical trials will confirm the magnitude of benefit suggested by preclinical and early observational data

Excessive glucocorticoid production and/or elevated basal glucocorticoids, as can occur with chronic stress and mood disorders ( EARLY LIFE HPA AXIS DEVELOPMENT AND ITS EFFECTS ON EATING BEHAVIOR Lifetime experience, whether acute or chronic, clearly shapes both HPA axis and eating behavior

Others use continuous protocols

Fibroblasts, the cells responsible for producing collagen, become less active with each passing decade

The data indicated that more cells showed senescent phenotype in keloids