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3a) Consistent with a deleterious role for free iron in ASCVD, ApoE-/- mice exposed to chronic iron overload displayed exacerbated atherosclerosis likely secondary to VEC damage or death, which was attenuated by dietary iron restriction or iron chelation 62,63

There's at least some improvement trend, even if small

Under the dual pressure of chemotherapy drugs and elesclomol, cancer cells face opposing pressures, which may help prevent the development of drug resistance

p21 interacts with cyclin dependent kinases (CDKs), thus maintaining RB in a hypophosphorylated state and inhibiting cell cycle progression (Harper et al., 1993

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