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Kenny et al., 2009)

In AIH, it has been proved that a signaling pathway mediated by hydrocarbon receptor (AhR) was necessary for ongoing AIH-like pathology, and Lactobacillus reuteri could release an AhR ligand, indole-3-aldehyde (I3A), thus promoting the differentiation of CD8 T cells in vitro and AIH-like pathology in mice [69]

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The reductionist model has stagnated pharmacological research, which has not produced any substantial innovation for approximately half a century, particularly for the treatment of depression, the level of effectiveness of which is modest [17] and antidepressant drug mechanisms shrouded in fog [10]