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Conversely, the model group exhibited a significant elevation in immobility time, indicative of an insomnia-induced depressive-like state

The IC50 values of DOX, DOX (AMF), Fe 3 O 4 @GOX@DOX@RBM, Fe 3 O 4 @GOX@DOX@RBM (AMF), and Fe 3 O 4 @GOX@DOX@RBM@FA groups were 4.89, 1.85, 2.56, 1.33, and 1.76 g/mL, respectively