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10.2174/187221308786241929 154 PaeH

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IGF-1 LR3s ability to cross the blood-brain barrier (reported in some animal models, though this is dose and model dependent) has made it a tool for examining central nervous system IGF1R effects

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Consistent with the above bioinformatic analyses, these results further confirm that human IDD is characterized by a redox imbalance, ferroptosis activation, and inflammatory stress, suggesting an intricate interplay among these factors throughout the IDD cascade