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Abstract The first and highly conserved step in glutathione (GSH) biosynthesis is formation of -glutamyl cysteine by the enzyme glutamate-cysteine ligase (GshA)

The viral S-protein and the ORF9b subunits could alter human cardiomyocyte metabolism and significantly impair the contractile function of the heart 119

The result is a single injectable solution containing both the peptide and the vitamin

While targeting glutamine pathwaysparticularly GLS1 and -KG metabolismpresents promising antifibrotic potential, the cell type-specific and compensatory mechanisms highlight the need for precise therapeutic strategies to effectively harness glutamine-targeted interventions in IPF (Fig

Abbreviations The following abbreviations are used in this manuscript: Author Contributions Conceptualization: D.Z., Q.M.P., A.S., C.W