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, is a more potent tumor suppressor than wild-type Rb, we integrated a vector containing doxycycline-inducible Rb alleles into a Kras +/G12D ;Trp53 -/- mouse pancreatic ductal adenocarcinoma cell line (Mazur et al., 2015) (Figure 6A, S6C, and S6D)

Novus Biologicals), phospho-IRS1 S1097 (2385

R This pathway is the primary defense against: Aflatoxin B1 (a carcinogenic mycotoxin produced by Aspergillus) Cadmium Epoxides (reactive Phase I intermediates from polycyclic aromatic hydrocarbons) Lipid peroxidation products (4-hydroxynonenal, malondialdehyde) Mercury (organic and inorganic forms) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) GSTs exist in three locations: cytosolic (the largest class, with alpha, mu, pi, theta, sigma, omega, and zeta subfamilies), mitochondrial (kappa class), and microsomal (MAPEG family)