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Many of these side effect can be reduced by using a lower concentration of steroid solution and spreading it out evenly over the area with multiple injections of small volumes, using a very fine syringe

Myers KA (2023) SCN1A as a therapeutic target for Dravet syndrome

Physiol Rev (2011) 91(3):1071121

E.BandellM.CosteB.Louis-Dit-PicardH.MathurJ.et al

Specifically, certain vitamin and mineral deficiencies have been clinically linked to periorbital hyperpigmentation (the medical term for dark discoloration under the eyes), and the mechanisms are real, if still being studied