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PMC 8457767

Further analysis via western blot and DNA fragmentation ELISA analysis showed that TNF addition increased PARP cleavage (a marker of apoptosis

These studies mainly focused on increased oxidative damage (Shao et al., 2006), impaired neuroprotective responses (Shimamura et al., 2004), worse blood brain barrier damage (Onyszchuk et al., 2008), and excessive pro-inflammatory responses in the thalamus (Sandhir et al., 2004), hippocampus (Sandhir et al., 2008), and cortex (Sandhir and Berman, 2010)

Our experimental design measured oxygen consumption kinetics and browning intensity caused by polyphenol oxidases, tyrosinase, and laccase