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The principal research objective of this multicenter double-blinded randomized placebo controlled trial was to determine the dose required to achieve physiological melatonin blood levels in preterm infants, similar to that of the mother and to define its pharmacokinetic profile in preterm infants

Cells sense nutrient levels and adjust their behavior through various interconnected pathways, including activation of AMPK and shutdown of mTOR pathway and engagement of various transcription factors (e.g., FOXOs, PGC-1), resulting in activation of autophagy, mitophagy DNA repair, and oxidative stress defense (Hofer et al., 2022)

10.1002/jbmr.4279 190 ViolaA.MunariF.Snchez-RodrguezR.ScolaroT.CastegnaA

Additionally, GA exhibits potent antioxidant capacity, significantly increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum, thereby mitigating oxidative damage (Shi et al., 2021)