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Additionally, the authors acknowledge the general positive bias of the published results, the lack of replicative validation studies, and the resulting risk of overestimating treatment efficacy in preclinical models that would provide confidence for the current findings and improve translational significance

doi:10.1515/9781501511455

5 The role of biotransformation in uncovering the active substance The intricate connection between many natural compounds poor oral availability and significant pharmacological efficacy is being uncovered by studies on gut microbiota

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2001;109(Suppl 6):911-933 Ahlbom A