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In macrophages infected with Leishmania donovani , activation of PINK1/Parkin-mediated mitophagy reduces mtROS accumulation and prevents uncontrolled inflammasome activation ( 5.5 Parasite-induced mitochondrial signaling and immune evasion Mitochondria orchestrate several innate immune pathways critical for parasite control, including NLRP3 inflammasome activation and type I interferon responses

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Glutathione (GSH), also known as -L-glutamyl-L-cysteinyl-glycine, is required in the maintenance and regulation of the thiol-redox status [16]

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