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Given the limited treatment options for these liver injuries, understanding the mechanisms and modes of cell death is crucial for identifying novel therapeutic targets

In some cases, the mechanism of injury is unknown, e.g

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Cells with genetic predispositions, such as those with mutations in the MC1R gene or lower melanin levels, exhibit impaired DNA repair mechanisms, increasing their susceptibility to melanoma development 54

The musculoskeletal system is a comprehensive and interconnected system, and diabetic patients with muscle wasting syndrome are more prone to developing osteoporosis, and lower muscle mass and strength, along with higher fat content, can impair bone quality (Herrmann et al., 2020)