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Nitrous oxide, a commonly used anesthetic, oxidizes and inactivates vitamin B 12 , thus inhibiting both of the vitamin B 12 -dependent enzymes, and can produce many of the clinical features of vitamin B 12 deficiency, such as megaloblastic anemia and neuropathy

Stanley and colleagues, in the Journal of Clinical Endocrinology and Metabolism in 2011, demonstrated the mechanistic reason

doi: 10.1215/15228517-2008-095 231 BernardiRJLoweryARThompsonPABlaneySMWestJL

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