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The methylated ring nitrogen gives the molecule a positive charge

Clinical studies are scarce on the treatment of liver disease, with a notable absence of high-quality clinical trials to substantiate its safety and efficacy

Biochim Biophys Acta Proteins Proteom 1867(10):890908

While many of the biomaterials that have been developed for the delivery of pro-angiogenic factors focus on delivery of large proteins, this review focuses on identifying materials that can be adapted for delivery of the many promising pro-angiogenic peptides that have been identified, as well as materials designed specifically for peptide delivery